High-frequency ultrasound

The Vevo LAZR-X Imaging System includes a Vevo 3100 Imaging System and a Class IV Laser, and it is a versatile multi-modality imaging platform based on the Vevo 3100 which combines high resolution anatomical visualization with functional data such as oxygen saturation, hemodynamics and biomarker microdistribution. The Vevo 3100 Imaging System (echocardiography) is a software-controlled device that acquires and displays high-resolution, real-time ultrasound images, and it provides various imaging modes. B-Mode displays echoes in a two-dimensional view by assigning a brightness level based on the echo signal amplitude. B-Mode is the most effective mode for locating anatomical structures. We can create a Volume Measurement in B-Mode 3D (3D-Mode). For motion mode (M-Mode) LV trace measurements, specify which heart rate values should be used for calculation. M-Mode is used primarily to measure the movement and dimensions of cardiac structures such as chambers and walls. M-Mode works fundamentally differently than B-Mode. Where B-Mode is a frame-based image that uses multiple scanning beams to create its image, M Mode is a time-based image that uses just one beam. Time-base imaging modes capture images measured in seconds, based on unique source data characteristics. Notably, the system can deliver a maximal frame rate of 1,000 frames per second. Vevo Strain software is the only commercial strain analysis package optimized for assessing myocardial abnormalities and therapeutic interventions. In addition, Nonlinear Contrast (NLC) Mode is a high-frequency imaging mode that produces improved sensitivity in microbubble detection and quantification. This mode suppresses the tissue signal while increasing the detection of the contrast agents. Briefly, the Vevo 3100 Imaging system has some features and benefits as follows:

  • High-frequency ultrasound:
  • With a powerful combination of high frame rates and advanced image processing, the Vevo 3100 reduces speckle noise and artifacts while preserving and enhancing critical information for small animal in vivo studies.
  • Monitor the animal’s ECG, heart rate, respiration and core body temperature and display and record this data in real time
  • State-of-the-art Ultra High Frequency - up to 70 MHz
  • Resolution down to 30 µm
  • Dedicated LZ-series transducers with integrated light delivery
  • Customizable workflow for rapid data acquisition