Year 2021

Fan S. Z., Lin C. S., Wei Y. W., Yeh S. R., Tsai Y. H., Lee A. Ch., Lin W. S., Wang P. Y. Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis. Aging Cell. 2021; 20(12): e13510.

Huang T. H., Chang H. H., Guo Y. R., Chang W. C., Chen Y. F. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22(21):11737.

Wu K. C., Lee D. Y., Hsu J. T., Cheng C. F., Lan, J. L., Chiu S. C., Cho D. Y., Hsu J. L. Evaluations and Mechanistic Interrogation of Natural Products Isolated From Paeonia suffruticosa for the Treatment of Inflammatory Bowel Disease. Front. Pharmacol. 2021; 12:696158.

Su C. H., Liao W. J., Ke W. C., Yang R. B., Tarn W. Y. The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia. iScience 2021; 24 (11): 103368.

Chen F. J., Hsiao Y. S., Liao I. H., Liu C. T., Wu P. I., Lin C. Y., Cheng N. C., Yu J. Rational design of a highly porous electronic scaffold with concurrent enhancement in cell behaviors and differentiation under electrical stimulation. Journal of Materials Chemistry B 2021;9(37):7674-7685.

Kuo T. F., Hsu S. W., Huang S. H., Chang C. L. T., Feng C. S., Huang M. G., Chen T. Y., Yang M. T., Jiang S. T., Wen T. N., Yang C. Y., Huang C. Y., Kao S. H., Tsai K. C., Yang G., Yang W. C. Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy. EMBO Mol Med 2021;13:e11668.

Jiang C. L., Chen Y. F., Lin F. J. Apolipoprotein E deficiency activates thermogenesis of white adipose tissues in mice through enhancing β-hydroxybutyrate production from precursor cells. FASEB J. 2021;35(8):e21760.

Tseng T. L., Wang Y. T., Tsao C. Y., Ke Y. T., Lee, Y. C., Hsu H. J., Poss K. D., Chen C. H. The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Development 2021;148(15):dev199578.

Fu H. I., Hsu J. H., Li T. J., Yeh S. H., Chen C. C. Safety assessment of HEA-enriched Cordyceps cicadae mycelia on the central nervous system (CNS), cardiovascular system, and respiratory system in ICR male mice. Food Science & Nutrition 2021; 9(9): 4905-4915.

Chen S. P., Chen, E. H., Yang, S. Y., Kuo, P. S., Jan, H. M., Yang, T. C., Hsieh, M. Y., Lee, K. T., Lin, C. H., Chen, R. P. A systematic study of the stability, safety, and efficacy of the de novo designed antimicrobial peptide pepD2 and its modified derivatives against Acinetobacter baumannii. Front. Microbiol. 2021; 12:678330.

Wagner B. M., Robinson J. W. , Lin Y. W., Lee, Y. C., Kaci N., Legeai-Mallet L., Potter L. R. Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism. JCI insight 2021; 6(9): e147832.

Chen S. Y., Chen Y. Z., Lee Y. J., Jiang C. L., Lu S. C., Lin F. J. Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype. J Nutr Biochem. 2021;90:108575.

Chang S. H., Su Y. C., Chang M., Chen J. A. MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs. eLife 2021;10:e63768

Pan J. K., Lin C. H., Kuo Y. L. , Ger L. P., Cheng H. C. , Yao Y. C., Hsiao M., Lu P. J. MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer. Oncogene. 2021;40(9):1737-1751.

Yang C. Y., Lu R. J., Lee M. K., Hsiao F. S., Yen Y. P., Cheng C. C., Hsu P. S., Tsai Y. T., Chen S. K., Liu I. H., Chen P. Y., Lin S. P. Transcriptome Analysis of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation. Front Cell Dev Biol. 2021;9:615098.

Huang Y. L., Huang M. T., Sung P. S., Chou T. Y , Yang R. B., Yang A. S., Yu C. M., Hsu Y. W., Chang W. C., Hsieh S. L. Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Commun Biol. 2021;4(1):229.

Chen C. Y., Lee D. S., Choong O. K., Chang S. K., Nicholson, M. W., Liu L. W., Lin P. J., Ruan S. C., Lin S. W., Hu C. Y. and Hsieh P. C. Cardiac-specific MicroRNA-125b deficiency induces perinatal death and cardiac hypertrophy. Sci Rep. 2021;11(1):2377.

Lin Y. C., Niceta M., Muto V., Vona B., Pagnamenta A. T, Maroofian R., Beetz C., Duyvenvoorde H. van, Dentici M. L., Lauffer P., Vallian S., Ciolfi A., Pizzi S., Bauer P., Grüning N. M., Bellacchio E., Fattore A. D., Petrini S., Shaheen R., Tiosano D., Halloun R., Pode-Shakked B., Albayrak H. M., Işık E., Wit J. M., Dittrich M., Freire B. L., Bertola D. R., Jorge A. A. L., Barel O., Sabir A. H., Tenaiji A. M. J. A., Taji S. M., Al-Sannaa N., Al-Abdulwahed H., Digilio M. C., Irving M., Anikster Y., Bhavani G. S. L., Girisha K. M., Genomics England Research Consortium; Haaf T., Taylor J. C., Dallapiccola B., Alkuraya F. S., Yang R. B., Tartaglia M. SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am. J. Hum. Genet. 2021; 108(1):115-133.