Year 2025

Chee Ning Wong, Kai Bin Liew, Yang Mooi Lim, Yik-Ling Chew, Ang-Lim Chua, Shi-Bing Yang, Siew-Keah Lee Development and Characterization of EGCG-Loaded TPGS/Poloxamer 407 Micelles with Evaluation of In Vitro Drug Release and In Vivo Pharmacokinetics and Tolerability Observations Following Oral Administration. Pharmaceutics 2025;17(11):1441.

Hsiang Yun Lin, Tzu-Fan Chen, Tsung-Yu Tsai, Hen-Hong Chang, Zi-Lun Lai, Po-Ren Hsueh, Der-Yang Cho, Jye-Lin Hsu Banxia Xiexin Decoction prevents colitis by modulating gut microbiota and enhancing defensin and immunoglobulin A production. Phytomedicine 2025;148:157393.

Chung-Lin Jiang, Pei-Hsiang Lai, Po-Cheng Yang, Chia-Jung Lien, Hsueh-Ping Catherine Chu, Jian-Da Lin, Sung-Jan Lin, I-Shing Yu, Fu-Jung Lin Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome. Nature Metabolism 2025;7(10):2045-2066.

Chen-Guang Zhang, Chen-Yun Yeh, Sheng-Yun Hsu, Mridula Prakash, Adrian B Abarientos, Hsi-Ming Chiang-Hsieh, You-Yu Lin, Christopher Llynard D Ortiz, Lee-Wei Yang, Pi-Hui Liang, Han-Chung Wu, Yungling Leo Lee Dendritic cell-targeted liposomes for cancer immunotherapy via inhibition of aryl hydrocarbon receptor. J Nanobiotechnology 2025;23(1):683.

Long Chang, Yen-Hsuan Jean, Tien-Chieh Chang, Chung-Chih Tseng, Zhi-Kang Yao, Yu-Chen Lai, Hsiao-Lan Huang, Hsi-Wen Sun, Li-Hsueh Wang, Fu-Wen Kuo, Zhi-Hong Wen Cultivated Pocillopora acuta coral as a sustainable and effective biomaterial: enhanced osteogenic potential and structural integrity. Materials & Design 2025; 258:114610.

Lokesh Kumar Mende, Meng-Lin Lee, Yaswanth Kuthati, Shu-Yi Koh, Chih-Shung Wong Daflon Enhances Morphine Analgesia and Mitigates Tolerance in a Rat Neuropathic Pain Model. Pharmaceuticals (Basel) 2025;18(10):1513.

Yi-Ju Hsu, Mon-Chien Lee, Huai-Yu Fan, Yu-Ching Lo Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice. Nutrients 2025;17(19):3148

Yi-Ting Tsai, Yuan-Chuan Lin, Ming-Jen Cheng, Chun-Ming Shih, Chien-Sung Tsai, Ze-Hao Lai, Ching-Yi Wu, Chen-Wei Liu, Feng-Yen Lin, Yi-Wen Lin Lepidium meyenii Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury. Nutrients 2025;17(19):3033.

Su-Ching Chang, Tomoyuki Komai, Appukuttannair Biju Kumar, Tin-Yam Cha DNA barcoding and morphology demonstrate that the three nominal species of the “Glyphocrangon smithii species complex” represent a single species, G. smithii Wood-Mason in Wood-Mason & Alcock, 1891 (Decapoda: Caridea: Glyphocrangonidae). Journal of Crustacean Biology 2025;45(3):ruaf047.

Balchandar Navaneethan, Mehdi Salar Amoli, Yen-Ching Yang, Sarah Rezapourdamanab, Chiao-Yu Tseng, Yamini Singh, Chin-Lin Guo, Vahid Serpooshan, Chia-Fu Chou Scalable Biofabrication of Functional 3D Scaffolds via Synergy of Autopilot Single-Jet Electrospun 3D PCL Fiber Scaffolds and Cell-Laden Hydrogels. ACS Appl Mater Interfaces. 2025;17(34):47878-47893

Yu-Chien Lin, Susaritha Ramanathan, Huey-Yuan Wang, Ying-Chun Lin, Wai-Ching Liu, Julian R Jones, Nam-Joon Cho, Chih-Chien Hu, Ren-Jei Chung Engineered bioactive glass-chitosan hybrid for dual tissue and bone regeneration multifunctional healing. Biomater Adv. 2025;176:214340.

Wen-Tse Huang, Ming-Hsien Chan, Aishwarya Satpathy, Ting-Yi Su, Chien-Jung Chiu, Kuang-Mao Lu, Wen-Yu Hsieh, Bi-Chang Chen, Kung-Bin Sung, Michael Hsiao, Ru-Shi Liu Non-invasive photobiomodulation using near-infrared photon irradiation to alleviate amyloid-beta aggregation in Alzheimer’s disease. Microchemical Journal 2025;215:114196.

Keng-Mao Liao, Wei-Lun Hsu, Wan-Yi Huang, Wei-Jia Luo, Jung-Hsuan Chang, Sung-Liang Yu, Pan-Chyr Yang, Kang-Yi Su Brain miR-137 governs growth and development via GH/IGF-1 signaling. BMC Biol. 2025;23:197.

Tzu-Yu Cheng, Ting-Wei Lee, Shao-Jung Li, Ting-I Lee, Yao-Chang Chen, Yu-Hsun Kao, Satoshi Higa, Pao-Huan Chen, Yi-Jen Chen Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia. J Adv Res. 2025; 73:549-560.

Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, Siow-Wey Hee, Chi-Fon Chang, Hsin-Yung Yen, Yi-An Chen, Yet-Ran Chen, Ya-Wen Chou, Fu-An Li, Yi-Yu Ke, Shih-Yi Chen, Ming-Shiu Hung, Alfur Fu-Hsin Hung, Jing-Yong Huang, Chu-Hsuan Chiu, Shih-Yao Lin, Sheue-Fang Shih, Chih-Neng Hsu, Juey-Jen Hwang, Teng-Kuang Yeh, Ting-Jen Rachel Cheng, Karen Chia-Wen Liao, Daniel Laio, Shu-Wha Lin, Tzu-Yu Chen, Chun-Mei Hu, Ulla Vogel, Daniel Saar, Birthe B Kragelund, Lun Kelvin Tsou, Yu-Hua Tseng, Lee-Ming Chuang Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity. EMBO Mol Med. 2025;17(5):938-966.

Ya-Ping Yen, Ting-Hsiang Lung, Ee Shan Liau, Chuan-Che Wu, Guan-Lin Huang, Fang-Yu Hsu, Mien Chang, Zheng-Dao Yang, Chia-Yi Huang, Zhong Zheng, Wei Zhao, Jui-Hung Hung, Chuan He, Qing Nie, Jun-An Chen The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation. Nat Commun. 2025;16(1):4063.

Yu-Cheng Lai, Zhi-Kang Yao, Tien-Chieh Chang, Chien-Wei Feng, Tsu-Jen Kuo, Yi-Wei Luo, Yen-Hsuan Jean, Hugo Y-H Lin, Zhi-Hong Wen Dextromethorphan Inhibits Osteoblast Differentiation and Bone Regeneration of Rats With Subcritical-Sized Calvarial Defects. Environ Toxicol. 2025;40(4):650-663.

Mun-Teng Wong, Pei-Hsuan Lin, Wei-Chen Lin, Chi-Jiun Peng, Jon D Wright, Hui-Ju Lee , Hsing-Mao Chu, Carmay Lim, Tse Wen Chang 2FA-Platform Generates Dual Fatty Acid-Conjugated GLP-1 Receptor Agonist TE-8105 with Enhanced Diabetes, Obesity, and NASH Efficacy Compared to Semaglutide. J Med Chem. 2025;68(6):6178-6192.

Yen-You Lin, Chien-Chung Huang, Chih-Yuan Ko, Chun-Hao Tsai , Jun-Way Chang, David Achudhan, Chih-Hsin Tang Omentin-1 modulates interleukin expression and macrophage polarization: Implications for rheumatoid arthritis therapy. Int Immunopharmacol. 2025;149:114205.

Yu-Wei Lai, Yi-Nan Lee, Hung-I Yeh, Yih-Jer Wu, Wen-Hsiung Chan, Shih-Wei Wang, Chao-Feng Lin, Chun-Hsuan Lin, Yun-Fang Chen, Ching-Hu Chung Long-Term Safety Evaluation of Fluorescent Gold Nanoclusters Conjugated with α-Lipoic Acid: Insights from a Six-Month In Vivo Study. J Funct Biomater. 2025;16(3):89.

Chun-Mei Hu, Sui-Chih Tien, Yung-Chen Lo, Ching-Hsuan Huang, Yi-Ling Ko, Dan-Ni Wu, Jiin Horng Lee, Ying-Ta Wu, Hui-Ming Yu, Kuo-Ging Lin, Lee Zong-You, Wei-Chieh Cheng Innovative cyclic peptide disrupts IL-17RB-MLK4 interaction for targeted pancreatic cancer therapy. Biomed Pharmacother. 2025; 184:117892.

Tzung Cheng Ye, Shu-Ju Chao, Chih-Pin Huang The long-term effect of SiO2 nanoparticles in drinking water induces chronic kidney disease in a mouse model with modern dietary habits. Sustainable Environment Research 2025; 35:5.

Chia-Chang Huang, Ching-Hsiang Wang, Hsiao-Yun Yeh, Hung-Cheng Tsai, Ching-Wen Yang, Tzu-Hao Li, Chien-Wei Su, Ying-Ying Yang, Han-Chieh Lin, Ming-Chih Hou Peroxisome Proliferator-Activated Receptor α/γ and Cannabinoid Receptor 2 Agonist Attenuated Nonalcoholic Steatohepatitis Exosome-Related Abnormalities in Mice. The American Journal of Pathology 2025;195(2):188-203.

Li-Yang Chen, Pin-Lung Chen, Si-Tse Jiang, Hui-Lin Lee, Yen-Yu Liu, Alysa Chueh, Jing-Heng Lin, Caleb G Chen, Chung-Lieh Hung, Kate Hsu Increased Anion Exchanger-1 (Band 3) on the Red Blood Cell Membrane Accelerates Scavenge of Nitric Oxide Metabolites and Predisposes Hypertension Risks. Function (Oxf) 2025;6(1):zqae052.

Ding-Han Wang, Kim-Xuyen Nguyen, Trang Thi-Ngoc Tran, Po-Han Wu, Guang Hon, Yu-Min Lin, Yi-Chen Hsu, Cheng-Chieh Yang, Yu-Cheng Lin, Wun-Eng Hsu, Ming-Lun Hsu, Mu-Chen Yang Phosphotungstic acid-enhanced micro-computed tomography and RNA sequencing provide a new perspective on temporomandibular joint arthritis induced by complete Freund’s adjuvant and collagen-induced arthritis in rat models. Journal of Dental Sciences 2025;20(1):189-200.

Ying-Wen Wang, Ching-Wei Luo Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex. Cell Commun Signal. 2025;23(1):38.

Jing-Ying Huang, Pei-Shan Sung, Shie-Liang Hsieh Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection. Front Immunol. 2025;15:1513713.

Wan-Ting Huang, Tzong-Jih Cheng, Lin-Hsiang Huang, Yung-Te Hou Efficacy of a hydrogen–oxygen generator in treating cigarette smoke–induced chronic obstructive pulmonary disease in rats. Current Research in Toxicology 2025; 8: 100214.
Ching-Hsuan Chou, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ron Yang The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo. Int J Biol Sci. 2025;21(2):685-707.